Unit 1 Cell and Molecular Biology

This unit will introduce candidates to broad concepts of cell and molecular biology. Candidates would be expected to have covered the following topics in their self-directed studies: cell cycle, DNA replication, mitosis, meiosis, transcription, translation, the genetic code, types of RNA, RNA processing, amino acid structure, protein structure, post-translational modification.

Learning Outcomes

  • 1.1 Define the terms somatic cell, germ cell and gamete
  • 1.2 Explain the progression of events that occur during the cell cycle which leads from a single parent cell to two identical daughter cells
  • 1.3 Describe the processes involved in DNA replication
  • 1.4 Describe the events that take place in the production of somatic cells via mitosis
  • 1.5 Describe the events that take place in the production of gametes via meiosis
  • 1.6 Describe the processes and enzymes involved in transcription and translation
  • 1.7 Describe the central Dogma (DNA->RNA-> Protein)
  • 1.8 Describe the degenerate and universal nature of the genetic code and how the DNA sequence prescribes the RNA sequence and the amino acid sequence of polypeptides
  • 1.9 Explain the role of the different types of RNA in gene transcription
  • 1.10 Describe how RNA transcripts are processed with 5' capping and 3' polyadenylation
  • 1.11 Describe amino acid structure and how amino acids are assembled into polypeptides
  • 1.12 Explain the primary, secondary and tertiary structure of proteins
  • 1.13 Describe how proteins can be modified via post-translational processing

Resources

  • 1.1 Strachan and Read (2011) Human Molecular Genetics, Fourth Edition, Garland Science and Taylor and Francis Group, New York, USA
  • 1.2 Human Genetics and Genomics, 4th Edition Bruce Korf & Mira Irons 2012, Wiley-Blackwell
  • 1.3 Essentials of Genetics by W.S. Klug, M.R. Cummings, C.A. Spencer and M.A. Palladino ISBN-10: 0134047796, 2015 by Pearson publications